Mutations of c-Cbl in myeloid malignancies.

Figure 1

Schematic display of the c-Cbl structure

The various domains are given in colors, 4H: four helical bundle, EF: EF-hand calcium-binding domain, SH2: Src homology 2, L: linker helical region, P: proline-rich, U: Ubiquitin-binding domain. The phosphorylated tyrosines in the C-terminus allow docking of the indicated proteins and the frequently mutated region is highlighted.

Oncotarget. 2015 May 10;6(13):10689-10696.

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