Rational autologous cell sources for therapy of heart failure: Vehicles and targets for gene and RNA therapies

The combination of cell and gene therapy is rapidly raising clinical interest, although their combination has been under investigation for several decades. This is mainly due to the availability and feasibility of clinically relevant gene delivery options.

This review focuses on cell therapies for heart failure and their use combined with cardiac surgery as well as with gene therapy. The review also provides insight into how financial and authority-based decisions and restrictions influence research in this field. Particular focus is given to autologous cardiac cell therapy that can be applied concomitantly to a cardiac operation.

This review focuses on the possibilities for intraoperative processing and isolation of autologous cells, particularly atrial appendage-derived cells (AADCs) and cellular micrografts, and their straightforward use in cell transplantation for heart failure therapy.

We review the potential of autologous tissues to serve as sources for cell therapy and consider especially those tissues that are used in surgery but from which the excess is currently discarded as surgical waste. We compare the in-culture-expanded cells to the freshly isolated ones in terms of evidence-based cost-efficacy and their usability as gene and RNA therapy vehicles. We also review how financial and authority-based decisions and restrictions sculpt the landscape for patients to participate in academic-based trials. Finally, we provide an insightful example of AADCs isolation and processing for epicardial therapy during coronary artery bypass surgery.

Rational Autologous Cell Sources For Therapy of Heart Failure – Vehicles and Targets For Gene and RNA Therapies. Milla Lampinen, Antti Vento, Jari Laurikka, Johanna Nystedt, Eero Mervaala, Ari Harjula and Esko Kankuri. Current Gene Therapy. DOI:10.2174/1566523216666160104141809. Published VOLUME: 16 ISSUE: 1.

Contact our news editors

For any corrections of factual information, or to contact our editorial team, please see our contact page.

Please note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms of use.

Copyright Medical News Today: Excluding email/sharing services explicitly offered on this website, material published on Medical News Today may not be reproduced, or distributed without the prior written permission of Medilexicon International Ltd. Please contact us for further details.

Be the first to comment

Leave a Reply

Your email address will not be published.