Clinical and Technical Aspects of Genomic Diagnostics for Precision Oncology.

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Clinical and Technical Aspects of Genomic Diagnostics for Precision Oncology.

J Clin Oncol. 2017 Mar 20;35(9):929-933

Authors: Sheikine Y, Kuo FC, Lindeman NI

Abstract
The emergence of precision medicine has been predicated on significant recent advances in diagnostic technology, particularly the advent of next-generation sequencing (NGS). Although the chemical technology underlying NGS is complex, and the computational biology expertise required to build systems to facilely interpret the results is highly specialized, the variables involved in designing and deploying a genomic testing program for cancer can be readily understood and applied by understanding several basic considerations. In this review, we present key strategic decisions required to optimize a genomic testing program and summarize the technical aspects of different technologies that render those methods more or less suitable for different types of programs.

PMID: 28297627 [PubMed – in process]

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