Gastric Cancer Subtypes Found to Have Different Prognoses

NEW YORK (GenomeWeb) – The four subtypes of gastric cancer identified by the Cancer Genome Atlas project are associated with different prognoses, according to a new study.

In 2014, researchers from TCGA reported that they uncovered different molecular types of gastric cancer: one that was associated with Epstein-Barr virus infection, one with microsatellite instability, another with chromosomal instability, and one with genomic stability.

In a new study appearing in Clinical Cancer Research today, researchers from the US and South Korea found that gastric tumors could be classified into these four subtypes based on their gene expression patterns. Additionally, they reported that the EBV subtype was associated with the best prognosis and that the chromosomal instability subtype was the most likely to respond to adjuvant chemotherapy treatment.

“These findings, if confirmed, could provide some information for personalized medicine,” senior author Ju-Seog Lee from the University of Texas MD Anderson Cancer Center said in a statement. “As we learn more about the biological characteristics associated with each subtype, it will help determine which patients will benefit from immunotherapy, chemotherapy, or other treatment options.”

Lee and his colleagues examined gene expression data generated by TCGA for 262 gastric tumors and developed subtype-specific signatures

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