Human genomics projects and precision medicine.
Gene Ther. 2017 Aug 14;:
Authors: Carrasco-Ramiro F, Peiró-Pastor R, Aguado B
The completion of the Human Genome Project (HGP) in 2001 opened the floodgates to a deeper understanding of medicine. There are dozens of HGP-like projects which involve from a few tens to several million genomes currently in progress, which vary from having specialised goals or a more general approach. However, data generation, storage, management and analysis in public and private cloud computing platforms have raised concerns about privacy and security. The knowledge gained from further research has changed the field of genomics and is now slowly permeating into clinical medicine. The new precision (personalised) medicine, where genome sequencing and data analysis are essential components allows tailored diagnosis and treatment according to the information from the patient’s own genome and specific environmental factors. P4 (predictive, preventive, personalised and participatory) medicine is introducing new concepts, challenges and opportunities. This review summarises current sequencing technologies, concentrates on on-going human genomics projects, and provides some examples in which precision medicine has already demonstrated clinical impact in diagnosis and/or treatment.Gene Therapy accepted article preview online, 14 August 2017. doi:10.1038/gt.2017.77.
PMID: 28805797 [PubMed – as supplied by publisher]