New Methodologies in the Molecular Monitoring of CML.

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New Methodologies in the Molecular Monitoring of CML.

Curr Hematol Malig Rep. 2016 Apr;11(2):94-101

Authors: Yeung CC, Egan D, Radich J

Abstract
In chronic myeloid leukemia (CML), the BCR-ABL fusion gene is both the therapeutic target of tyrosine kinase inhibitors and the indisputable direct marker of disease burden. Thus, sensitive assays for BCR-ABL now drive therapeutic options and are good surrogates for short- and long-term outcomes. Because CML is such an ideal model, new methods are arising that should make testing in CML faster, more reliable, and reach a greater sensitivity. These methods should be able to be transferred to other hematological malignancies that have mutation markers.

PMID: 26946301 [PubMed – indexed for MEDLINE]

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