Lessons from single-cell transcriptome analysis of oxygen-sensing cells.

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Lessons from single-cell transcriptome analysis of oxygen-sensing cells.

Cell Tissue Res. 2017 Sep 08;:

Authors: Zhou T, Matsunami H

Abstract
The advent of single-cell RNA-sequencing (RNA-Seq) technology has enabled transcriptome profiling of individual cells. Comprehensive gene expression analysis at the single-cell level has proven to be effective in characterizing the most fundamental aspects of cellular function and identity. This unbiased approach is revolutionary for small and/or heterogeneous tissues like oxygen-sensing cells in identifying key molecules. Here, we review the major methods of current single-cell RNA-Seq technology. We discuss how this technology has advanced the understanding of oxygen-sensing glomus cells in the carotid body and helped uncover novel oxygen-sensing cells and mechanisms in the mice olfactory system. We conclude by providing our perspective on future single-cell RNA-Seq research directed at oxygen-sensing cells.

PMID: 28887696 [PubMed – as supplied by publisher]

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