The microbiome and cancer.
J Pathol. 2018 Jan 27;:
Authors: Goodman B, Gardner H
Humans coexist with a vast bacterial, fungal, and viral microbiome with which we have coevolved for billions of years. The oncogenic mechanisms of particular bacteria with longstanding epidemiological relationships are increasingly understood at the molecular level. At the same time the arrival of next generation sequencing technology has permitted a thorough exploration of microbiomes such as that of human gut, enabling observation of taxonomic and metabolomic relationships between the microbiome and cancer. These studies have revealed causal mechanisms for both microbes within tumors and microbes in other host niches separated from tumors, mediated through direct and immunological mechanisms.
PMID: 29377130 [PubMed – as supplied by publisher]