Single-Cell RNA Sequencing: Unraveling the Brain One Cell at a Time.
Trends Mol Med. 2017 Jun;23(6):563-576
Authors: Ofengeim D, Giagtzoglou N, Huh D, Zou C, Yuan J
Single-cell RNA sequencing (scRNA-seq) is an exciting new technology allowing the analysis of transcriptomes from individual cells, and is ideally suited to address the inherent complexity and dynamics of the central nervous system. scRNA-seq has already been applied to the study of molecular taxonomy of the brain. These works have paved the way to expanding our understanding of the nervous system and provide insights into cellular susceptibilities and molecular mechanisms in neurological and neurodegenerative diseases. We discuss recent progress and challenges in applying this technology to advance our understanding of the brain. We advocate the application of scRNA-seq in the discovery of targets and biomarkers as a new approach in developing novel therapeutics for the treatment of neurodegenerative diseases.
PMID: 28501348 [PubMed – indexed for MEDLINE]