[Advance in molecular genetic research on X-linked syndromic hearing impairment].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2017 Dec 10;34(6):928-933
Authors: Huang M, Zhang D
In addition to hearing impairment, syndromic hearing impairment is often accompanied by disorders of urinary, skeletal, muscular, nervous, and ocular systems. Genetic factors have shown to play an important role in the pathogenesis of deafness. Mutations of X-linked genes may cause syndromic hearing impairment. Gene mapping, linkage analysis and next-generation sequencing may facilitate delineation of the pathogenesis of X-linked syndromic hearing impairment. This article reviews recent progress in molecular genetic research on X-linked syndromic hearing impairment, which may shed light for the diagnosis and treatment of these diseases.
PMID: 29188633 [PubMed – indexed for MEDLINE]