Organism and Microbiome Analysis: Techniques and Implications for Chronic Rhinosinusitis.

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Organism and Microbiome Analysis: Techniques and Implications for Chronic Rhinosinusitis.

Otolaryngol Clin North Am. 2017 Jun;50(3):521-532

Authors: Halderman AA, Lane AP

Abstract
Modern advances in DNA sequencing have allowed for the development of culture-independent techniques with application to infectious and inflammatory conditions, such as rhinosinusitis. Although paradigm-changing discoveries have resulted from molecular microbiologic methods for a number of diseases, insights provided into the role of bacteria in chronic rhinosinusitis have yet to be fully understood to the point of impacting clinical diagnosis and management. As culture-independent techniques continue to evolve and become more refined, it is likely that a better understanding will emerge of how the microbiome influences chronic rhinosinusitis pathogenesis and response to therapy.

PMID: 28318535 [PubMed – indexed for MEDLINE]

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