Organism and Microbiome Analysis: Techniques and Implications for Chronic Rhinosinusitis.
Otolaryngol Clin North Am. 2017 Jun;50(3):521-532
Authors: Halderman AA, Lane AP
Modern advances in DNA sequencing have allowed for the development of culture-independent techniques with application to infectious and inflammatory conditions, such as rhinosinusitis. Although paradigm-changing discoveries have resulted from molecular microbiologic methods for a number of diseases, insights provided into the role of bacteria in chronic rhinosinusitis have yet to be fully understood to the point of impacting clinical diagnosis and management. As culture-independent techniques continue to evolve and become more refined, it is likely that a better understanding will emerge of how the microbiome influences chronic rhinosinusitis pathogenesis and response to therapy.
PMID: 28318535 [PubMed – indexed for MEDLINE]