The role of Next-Generation Sequencing in tumoral radiosensitivity prediction.

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The role of Next-Generation Sequencing in tumoral radiosensitivity prediction.

Clin Transl Radiat Oncol. 2017 Apr;3:16-20

Authors: Bibault JE, Tinhofer I

Abstract
Technological advances have led to more precise radiation delivery, which has resulted in significant clinical gains. A better understanding of tumoral radiosensitivity is still needed to develop strategies and further personalize radiation treatments. Next-Generation Sequencing (NGS) and system biology have significantly transformed the field of oncology in the last two decades, but have only a few clinical applications in radiation oncology. This review describes the technical aspects and evolutions of NGS and discusses the latest clinical applications of genomics to predict tumoral radiosensitivity.

PMID: 29658008 [PubMed]

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