Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains.

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Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains.

Proc Natl Acad Sci U S A. 2017 08 22;114(34):9158-9163

Authors: Timmermans S, Van Montagu M, Libert C

Abstract
Mouse inbred strains remain essential in science. We have analyzed the publicly available genome sequences of 36 popular inbred strains and provide lists for each strain of protein-coding genes that acquired sequence variations that cause premature STOP codons, loss of STOP codons and single nucleotide polymorphisms, and short in-frame insertions and deletions. Our data give an overview of predicted defective proteins, including predicted impact scores, of all these strains compared with the reference mouse genome of C57BL/6J. These data can also be retrieved via a searchable website (mousepost.be) and allow a global, better interpretation of genetic background effects and a source of naturally defective alleles in these 36 sequenced classical and high-priority mouse inbred strains.

PMID: 28784771 [PubMed – indexed for MEDLINE]

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