Towards a Universal Molecular Microbiological Test.

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Towards a Universal Molecular Microbiological Test.

J Clin Microbiol. 2017 Nov;55(11):3175-3182

Authors: Allcock RJN, Jennison AV, Warrilow D

The standard paradigm for microbiological testing is dependent on the presentation of a patient to a clinician. Tests are then requested based on differential diagnoses using the patient’s symptoms as a guide. The era of high-throughput genomic methods has the potential to replace this model for the first time with what could be referred to as “hypothesis-free testing.” This approach utilizes one of a variety of methodologies to obtain a sequence from potentially any nucleic acid in a clinical sample, without prior knowledge of its content. We discuss the advantages of such an approach and the challenges in making this a reality.

PMID: 28835478 [PubMed – indexed for MEDLINE]

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