Does next-generation sequencing of cyst fluid improve management of pancreatic cystic neoplasms?
Scand J Gastroenterol. 2017 Oct;52(10):1049-1051
Authors: Aronsson L, Andersson R, Swahn F, Ansari D
Pancreatic cystic lesions represent a heterogeneous group of diseases ranging from benign to malignant lesions. They are increasingly being detected due to the widespread use of cross-sectional imaging. Their management is a challenge because it is often not possible to reliably discriminate between malignant and nonmalignant lesions using current imaging technology. Next-generation sequencing (NGS) has the ability of both whole genome and targeted sequencing at a low cost and from a limited amount of DNA. NGS of cyst fluid aspired by endoscopic ultrasonography-guided fine-needle aspiration provides a valuable tool in biomarker research and may in the future help improve diagnosis and management of pancreatic cystic lesions.
PMID: 28678564 [PubMed – indexed for MEDLINE]