BRAF Proficiency Testing Reporting Adequate But Could Improve, Analysis Finds

NEW YORK (360Dx) – Laboratories participating in BRAF proficiency testing through the College of American Pathologists are reporting most of the required information, but still have room for improvement, according to a recently published analysis.

Overall, researchers said that laboratories participating in BRAF proficiency testing through CAP include most of the required reporting elements “to unambiguously convey molecular results,” and but they “should continue to strive to report these results in a concise and comprehensive manner.”

Published in the Archives of Pathology and Laboratory Medicine, the report set out to examine whether laboratories followed CAP instructions in reporting required information to clinicians and patients. The researchers examined the reporting of basic information, such as the name of the facility, the date that a patient specimen was collected, and the specimen type.

Additionally, it looked at which technologies the labs used and whether they adequately defined the targets of their assays.

The researchers looked at a total of 107 evaluable reports — 57 demonstrating positive results for the BRAF V600E mutation, and 50 negative. Among the more notable findings: PCR with probe discrimination was the most common method used for mutation detection, followed by Sanger sequencing, allele-specific primers, and pyrosequencing. Only

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