From Marine Venoms to Drugs: Efficiently Supported by a Combination of Transcriptomics and Proteomics.
Mar Drugs. 2017 Mar 30;15(4):
Authors: Xie B, Huang Y, Baumann K, Fry BG, Shi Q
The potential of marine natural products to become new drugs is vast; however, research is still in its infancy. The chemical and biological diversity of marine toxins is immeasurable and as such an extraordinary resource for the discovery of new drugs. With the rapid development of next-generation sequencing (NGS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS), it has been much easier and faster to identify more toxins and predict their functions with bioinformatics pipelines, which pave the way for novel drug developments. Here we provide an overview of related bioinformatics pipelines that have been supported by a combination of transcriptomics and proteomics for identification and function prediction of novel marine toxins.
PMID: 28358320 [PubMed – in process]